PUBLICATIONS
2024
77. N. Bin Abdullah, M. Taylor, A. Al-Dargazelli, M. Benito Montaner, F. Kareem, A. Locks, Z. Cao, B. Bowles, S. Schafhauser, J-C. Sarraf, T. Fajinmi, Z. Muwaffak, C. Beckwith, G. N. Parkinson, Z. A. E. Waller, B. R. Szulc and S. T. Hilton, Breaking the Access to Education Barrier: Enhancing HPLC Learning with Virtual Reality Digital Twins, Submitted to Journal of Chemical Education, 2024.
76. A. Al-Dargazelli, A. Locks, M. Taylor, S. T. Hilton, HPLC Training for All: Integration of Multi-Language Artificial Intelligence (AI) Avatars in Virtual Reality (VR) Digital Twin Laboratories, ChemRxiv, 2024, https://doi.org/10.26434/chemrxiv-2024-q511z.
74. S. K. Mansell, S. Mandal, D. Ridout, O. Olsen, F. Gowing, C. Kilbride, S. Hilton, E. Main, S. Schievano, The clinical impact of customised Positive Airway Pressure (PAP) therapy interfaces vs usual care in the treatment of patients with sleep disordered breathing: a randomised controlled trial protocol, submitted to Contemporary Clinical Trials, 2024.
2023
70. M. Taylor, Z. Muwaffak, M. R. Penny, B. R. Szulc, S. Brown, A. Merritt, S. T. Hilton, The Rise of the AI Scientist: Unleashing the Potential of Chat-GPT Powered Avatars in Virtual Reality Digital-twin Laboratories, ChemRxiv, 2023, https://doi.org/10.26434/chemrxiv-2023-t4vg7.
68. B. C. Sil, J. Frost, Z. Muwaffak, Q. Wong, M. R. Penny, S. T. Hilton, The development of the MiniXtruder: a low-cost laboratory scale filament extruder with reduced internal dead volume for 3D Printing, ChemRxiv 2023, 10.26434/chemrxiv-2023-0s2tq.
67. N. Bin Abdullah, M. Taylor, A. Al-Dargazelli, M. Benito Montaner, F. Kareem, A. Locks, Z. Cao, B. Bowles, S. Schafhauser, J-C. Sarraf, T. Fajinmi, Z. Muwaffak, C. Beckwith, G. N. Parkinson, Z. A. E. Waller, B. R. Szulc and S. T. Hilton, Breaking the Access to Education Barrier: Enhancing HPLC Learning with Virtual Reality Digital Twins, ChemRxiv 2023. 10.26434/chemrxiv-2023-c28km.
66. B. Szulc and S. Hilton, Virtual reality training in pharma: just a headset away? European Pharmaceutical Review, 2023, article -179036.
65. M. Benito Montaner, M. R. Penny and S.T. Hilton, Digitisation of a modular plug and play 3D printed continuous flow system for chemical synthesis, Digital Discovery, 2023, 2, 1797 - 1805.
64. M. R. Penny and S.T. Hilton, 3D printed reactors and Kessil lamp holders for flow photochemistry: design and system standardization. J Flow Chem 2023, 13, 435–442.
63. M. R. Penny, Z. X. Rao, R. Thavarajah, A. Ishaq, B.J. Bowles, S. T. Hilton, 3D printed tetrakis(triphenylphosphine)palladium (0) impregnated stirrer devices for Suzuki-Miyaura cross-coupling reactions, Reaction Chemistry and Engineering, 2023, 8, 752-757.
62. S. Gaware, S. Kori, J. L. Serrano, R. Dandela, S. T. Hilton, Y. S. Sanghvi, A. R. Kapdi, Rapid plugged flow synthesis of nucleoside analogues via Suzuki-Miyaura coupling and heck Alkenylation of 5-Iodo-2’-deoxyuridine (or cytidine). J Flow Chem 2023, 13, 293–310.
2022
61. S. T. Hilton, Using the pandemic as a driver for innovation in research, Nature Reviews Methods Primers, 2022, 2, 17.
60. M. Saviano, B. J. Bowles, M. R. Penny, A. Ishaq, Z. Muwaffak, G. Falcone, P. Russo, S. T. Hilton*, Development and analysis of a novel loading technique for FDM 3D printed systems: Microwave-assisted impregnation of gastro-retentive PVA capsular devices, International Journal of Pharmaceutics, 2022, 613, 1213866.
2021
59. L. Walmsley, S. Hilton ,E. Sellier ,M. Penny ,D. Maddox., Control and Monitoring of Temperature in 3D-Printed Circular Disk Reactors for Continuous Flow Photochemistry using Raspberry Pi Based Software, ChemRxiv 2021, 10.26434/chemrxiv-2021-cxs25.
58. M. R. Penny, N. Tsui and S.T. Hilton*, Extending practical flow chemistry into the undergraduate curriculum via the use of a portable low-cost 3D printed continuous flow system, Journal of Flow Chemistry, 2021, 11, 19-29.
2020
57. M. R. Penny and S.T. Hilton*, Design and Development of 3D Printed Catalytically Active Stirrers for Chemical Synthesis, Reaction Chemistry and Engineering, 2020, 5, 853-858.
56. B. C. Sil, R. B. Belgrave, M. P. Alvaraez, L. Luo, M. Cristofoli, M. R. Penny, D. J. Moore, J. Hardgraft, S. T. Hilton, M. E. Lane, 3D-Printed Franz Cells – An update on Manufacture and Evaluation, International Journal of Cosmetic Science, 2020, DOI - 10.1111/ics.12618.
2019
55. C.R.M. Asquith, B.C. Sil, T. Laitinen, G.J. Tizzard, S.J. Coles, A. Posso, R. Hofmann-Lehmann, S.T. Hilton*, Novel Epidithioketopiperazines as anti-viral zinc ejectors of the Feline Immunodeficiency Virus (FIV) nucleocapsid protein as a model for HIV Infection, Bioorganic and Medicinal Chemistry, 2019, 27, 4174-4184.
54. C.G. van Melis, M. R. Penny, A. D. Garcia, A. Petti, A.P. Dobbs, S.T. Hilton*, K. Lam*, Supporting‐Electrolyte‐Free Electrochemical Methoxymethylation of Alcohols Using a 3D‐Printed Electrosynthesis Continuous Flow Cell System ChemElectroChem, 2019, 6, 4144-4148.
53. M.R. Penny, Z.X.Rao, B.F. Peniche, S.T. Hilton*, Modular 3D Printed Compressed Air Driven Continuous-Flow Systems for Chemical Synthesis, European Journal of Organic Chemistry, 2019, 23, 3783-3787.
52. B. C. Sil, A. Patel, J.M. Crowther, D.J. Moore, J. Hardgraft, S.T. Hilton*, M.E. Lane*, A Preliminary Investigation of Additive manufacture to Fabricate Human Nail Plate Surrogates for Pharmaceutical Testing, Pharmaceutics, 2019, 11, 250.
51. C. R. M. Asquith, T. Laitinen, L. S. Konstantinova, G. Tizzard, A. Poso, O. A. Rakitin, R. Hofmann-Lehmann, S. T. Hilton*, Investigation of the Pentathiepin Functionality as an Inhibitor of Feline Immundeficiency Virus (FIV) via a Potential Zinc Ejection Mechanism, as a Model for HIV Infection, ChemMedChem, 2019, 14, 454-461.
50. S. K. Talapatra, M. R. Penny, S. T. Hilton, F. Kozielski*, Design, 3D-printing and validation of high capacity sitting drop bridges for increased protein crystallisation, Journal of Applied Crystallography, 2019, 52, 171-174.
2018
49. C. R. M. Asquith, L. S. Konstantinova, T. Laitinen, S. J. Coles, O. A. Rakitin, S. T. Hilton*, Exploration and development of a C-H activated route to access the [1,2]dithiolo[4,3-b]indole-3(4H)-thione core and related derivatives, Synlett, 2018, 30, 156-160.
48. B. C. Sil, M. P. Alvarez, Y. Zhang, C.-P Kung, M Hossain, F Iliopoulos, L Luo, J M. Crowther, D J. Moore, J. Hadgraft, M. E. Lane and S. T. Hilton*, 3D printed Franz type diffusion cells, International Journal of Cosmetic Science, 2018, 40(6), 604-609.
47. J. Li, Y. Zhang, B. Sil dos Santos, F. Wang, Y. Ma, C. Perez, Y. Yang, J. Pneg, S. M. Cohen, T-F. Chou, S. T. Hilton, R. J. Deshaies*, Epidithiodiketopiperazines inhibit protein degradation by targeting proteasome deubiquitinase Rpn11, Cell Chemical Biology, 2018, 25, 1-9.
46. B. R. Szulc, S. T. Hilton, A. Ruiz *, Physiological signature of a novel potentiator of AMPA receptor signalling, Molecular and Cellular Neuroscience, 2018, 92, 82-92.
45. L.V. Kerai, J. Bardes, S. Hilton, S. Murdan*, Two strategies to enhance ungual drug permeation from UV-cured films: Incomplete polymerisation to increase drug release and incorporation of chemical enhancers, European Journal of Pharmaceutical Sciences 2018,123, 217-227.
2017
44. S.A. Mohammed, M.E. Vianna, M.R. Penny, S.T. Hilton, N. J. Mordan and J.C. Knowles*, Investigations into in situ Enterococcus faecalis biofilm removal by passive and active sodium hypochlorite irrigation delivered into the lateral canal of a simulated root canal model, Australian Endodontic Journal, 2017, doi:10.1111/iej.12880.
43. Z. X. Rao, B. Patel, A. Monaco, M. Barniol-Xicota, E. Pichon, M. Ladlow and S. T. Hilton*, 3D Printed Polypropylene Continuous-Flow Column Reactors: Exploration of Reactor Utility in SNAr Addition Reactions and the Synthesis of Bicyclic and Tetracyclic Heterocycles, European Journal of Organic Chemistry 2017, 6499-6504.
42. Z. Muwaffak, A. Goyanes, V. Clark, A. W. Basit, S. Gaisford*, S. T. Hilton*, Patient-specific 3D scanned and 3D printed antimicrobial polycaprolactone wound dressings, International Journal of Pharmaceutics 2017, 527, 161-170.
41. S.A. Mohammed, M.E. Vianna, M.R. Penny, S.T. Hilton, J.C. Knowles*, The effect of sodium hypochlorite concentration and irrigation needle extension on biofilm removal from a simulated root canal model, Australian Endodontic Journal, 2017, 10.1111/aej.12203.
40. A. Monaco, B. R. Szulc, Z. X. Rao, M. Barniol-Xicota, M. Sehailia, B. Borges and S. T. Hilton*, A Short Total Synthesis of (±)-g-Lycorane by a Sequential Intramolecular Acylal Cyclisation (IAC) and Intramolecular Heck Addition Reaction, Chemistry a European Journal, 2017, 23, 4750-4755.
39. S.A. Mohammed, M.E. Vianna, M.R. Penny, S.T. Hilton, N. Mordan, J.C. Knowles*, Confocal laser scanning, scanning electron, and transmission electron microscopy investigation of Enterococcus faecalis biofilm degradation using passive and active sodium hypochlorite irrigation within a simulated root canal model, MicrobiologyOpen. 2017, e00455.
38. M. Penny, Z. Jing Cao, B. Patel, B. Sil dos Santos, C. Asquith, B. R. Szulc, Z. X. Rao, Z. Muwaffak, J. P. Malkinson and S. T. Hilton*, 3D Printing of Scalable Molecular Models and an Orbital Kit for Organic Chemistry Teaching and Learning, Journal of Chemical Education, 2017, 94, 1265-1271.
37. S.A. Mohammed, M. E. Vianna, S. T. Hilton, D. R. Boniface, Y-L. Ng, J. C. Knowles*, Investigation to test potential stereolithography materials for development of an in vitro root canal model, Microscopy Research and Technique, 2017,80, 202-210.
2016
36. L.V. Kerai, S. Hilton, M. Maugueret, B.B. Kazi, J. Faull, S. Bhakta S, S. Murdan*, UV-curable gels as topical nail medicines: In vivo residence, anti-fungal efficacy and influence of gel components on their properties, International Journal of Pharmaceutics, 2016, 514, 244-254.
35. S.A. Mohammed, M.E. Vianna, M.R. Penny, S.T. Hilton, N. Mordan, J.C. Knowles*, A novel experimental approach to investigate the effect of different agitation methods using sodium hypochlorite as an irrigant on the rate of bacterial biofilm removal from the wall of a simulated root canal model, Dental Materials, 2016, 32, 1289-1300.
34. C. R. M. Asquith, M.L. Meli, L.S. Konstantinova, T.Laitinen, M.Peräkylä, A.Poso, O.A. Rakitin, R. Hofmann-Lehmann and S.T. Hilton* Evaluation of substituted 1,2,3-dithiazoles as inhibitors of the Feline Immunodeficiency Virus (FIV) nucleocapsid protein via a proposed zinc ejection mechanism, ChemMedChem 2016, 11, 2119-2126.
2015
33. B. R. Szulc, B. C. Sil, A. Ruiz and S. T. Hilton*, A Common Precursor Approach to Structurally Diverse Natural Products: The Synthesis of the Core Structure of (±)-Clausenamide and the Total Synthesis of (±)-Hyalodendrin, European Journal of Organic Chemistry 2015, 34, 7438-7442.
32. A. Monaco, A. E. Aliev, and S. T. Hilton*, Intramolecular Acylal Cyclisation (IAC) as an Efficient Synthetic Strategy towards the Total Synthesis of Erythrina Alkaloid Derivatives, Chemistry a European Journal 2015, 21, 13909–13912.
31. A. L. Tyson, S. T. Hilton*, L. C. Andreae, Rapid, simple and inexpensive production of custom 3D printed equipment for large-volume fluorescence microscopy, International Journal of Pharmaceutics 2015, 494, 651-656.
30. L. V. Kerai, S. T. Hilton S. Murdan*, UV-curable gel formulations: Potential drug carriers for the topical treatment of nail diseases, International Journal of Pharmaceutics 2015, 492, 177–190.
29. C.R.M. Asquith, M.L. Meli, L.S. Konstantinova, T.Laitinen, M.Peräkylä, A.Poso, O.A. Rakitin, K. Allenspach, R. Hofmann-Lehmann and S.T. Hilton*, Novel fused tetrathiocines as antivirals that target the nucleocapsid zinc finger containing protein of the Feline Immunodeficiency Virus (FIV) as a model of HIV infection Bioorganic and Medicinal Chemistry Letters 2015. 25, 1352-1355.
28. B. Patel and S.T. Hilton*, A radical mediated approach to the total synthesis of fluorinated marinoquinoline A and related tricyclic and tetracyclic congeners, Synlett 2015, 79-83.
2014
27 .C.R.M. Asquith, M.L. Meli, L.S. Konstantinova, T.Laitinen, M.Peräkylä, A.Poso, O.A. Rakitin, K. Allenspach, R. Hofmann-Lehmann and S.T. Hilton*, Evaluation of the antiviral efficacy of bis[1,2]dithiolo[1,4]thiazines and bis[1,2]dithiolopyrrole derivatives against the nucleocapsid protein of the Feline Immunodeficiency Virus (FIV) as a model for HIV infection, Bioorganic and Medicinal Chemistry Letters March 2014. 24, 2640–2644.
26. B. Patel, G. Saviolaki, T. Kapadia, C Ayats and S.T. Hilton*, Tunable radical cyclisations: A tin-free approach towards tricyclic and spirocyclic heterocycles via a common precursor approach, RSC Advances 2014, 4, 18930 - 18932.
2013
25. B. Sil, S.T. Hilton*, A Mild and Convenient Base Catalysed Approach to Disubstituted Epidithiodiketopiperazines, Synlett, 2013, 2563-2566.
24. S. Mpima, S. A. Ohnmacht, M. Barletta, J. Husby, L. Pett, M. Gunaratnam, S. T Hilton and S. Neidle*, The influence of positional isomerism on G-quadruplex binding and anti-proliferative activity in tetra-substituted naphthalene diimides, Bioorganic and Medicinal Chemistry, 2013, 21, 6162–6170.
2010-2000
23. D. Mirizzi, S.T. Hilton and K. Jones*, Heteroaryl Radicals Review, Advances in Heterocyclic Chemistry 2010, 100, 101-143.
22. S. Hilton, S. Naud, J.J. Caldwell, K. Boxall, S. Burns, V.E. Anderson, L. Antoni, C.E. Allen, L.H. Pearl, A.W. Oliver, G.W. Aherne, M.D. Garrett, I. Collins*, Identification and characterisation of 2-aminopyridine inhibitors of checkpoint kinase 2, Bioorganic and Medicinal Chemistry, 2010, 18, 707-718.
21. K.M. Cook, S.T. Hilton, J. Mecinovic, W.B. Motherwell, W.D. Figg, and C.J. Schofield*, Epidithiodiketopiperazines block the interaction between hypoxia inducible factor-1α (HIF-1α) and p300 by a zinc ejection mechanism, Journal of Biological Chemistry 2009, 284, 26831-26838.
20. S.T. Hilton and K. Jones*, The tandem radical route to indole alkaloids: an unusual rearrangement reaction, Arkivoc 2007, 120-128.
19. A. Aliev, S.T. Hilton, W.B. Motherwell*, D.L. Selwood, A concise approach to the Epidithiodiketopiperazine (ETP) core, Tetrahedron Letters 2006, 2387-2390.
18. S.T. Hilton, W.B. Motherwell*, P. Potier, C. Pradet and D. L. Selwood, Observations on the Reactivity of Thiyl Radicals derived from 3,6-Epidithiodiketopiperazine-2,5-diones and related congeners, Bioorganic and Medicinal Chemistry Letters 2005, 15, 2239-2242.
17. S. Denison and S.T. Hilton*, A convenient synthesis of 2-cyano-3-substituted indoles, Synlett 2004, 2806-2808.
16. S.T. Hilton, W.B. Motherwell*, D.L. Selwood, An Expedient Entry into the a-Mercaptodiketopiperazine Nucleus, Synlett 2004, 2609-2611.
15. S.T. Hilton, T.C.T. Ho, G. Pljevaljcic, M. Schulte, K. Jones*, A tandem radical approach to the ABCE-rings of the Aspidosperma and Strychnos alkaloids, Chemical Communications 2001, 209-210.
14. S.T. Hilton, T.C.T. Ho, G. Pljevaljcic, K. Jones*, A new route to Spirooxindoles, Organic Letters 2000, 2, 2639-2641.
Abstracts and Short Papers
13. M. Alband, R. M. Lee, M. Penny, S. Brocchini, S. T. Hilton, assessment of adhesion response to 3D printed materials for ophthalmic device development, Value in Health, 2016, 19, A564.
12. R. M. Lee, M. Alband, M. Penny, S. T. Hilton, S. Brocchini, P. T. Khaw, Cell adhesion and protein adsorption studies of 3D printed photopolymers, Investigative Ophthalmology and Visual Science, 2016, 57, A2923.
11. B. Szulc, A. Ruiz, S.T. Hilton, DHP compounds for memory enhancement, May 2013.
10. S.T. Hilton, The hypoxia inducible factor-1 alpha and p300 interaction as a therapeutic target of the epidithiodiketopiperazine class of natural products, Journal of Pharmacy and Pharmacology, 2009, 61, A152-A153, Abstract: 214.
9. K.M. Cook, S.T. Hilton, C.J. Schofield, W.D. Figg Sr., A promising cancer target: lead compounds blocking the HIF-1α/p300 interaction, In: Proceedings of the 99th Annual Meeting of the American Association for Cancer Research; 2008 Apr 12-16; San Diego, CA. Philadelphia (PA): AACR; 2008. Abstract nr 4149.
Patents
8. D. Waldmann, S. T. Hilton, Flow reactor and flow reactor assembly, and use of a pressurizing medium, Patent Application No. US17/065,996, 2020.
7. B. Dos Santos Sil, B. Patel, M. R. Penny, S. T. Hilton, Three-dimensional printing of impregnated plastics for chemical reactions, Patent Application No. WO2017158336A, 2016.
6. B. Szulc, A. Ruiz and S. Hilton, Compounds and Their Use in Therapy, Patent Application No PCT/GB2014/051391, 2013.
5. R. Brown, J. Plumb, G.W. Aherne, E. Mcdonald, K. Jones, S. Hilton, Preparation of 2-[3H]-thiazol-2-ylidine-methylpyridine and related compounds and their use as antitumor agents. PCT Int. Appl. WO. 2007096618, 2007.
Compiled Volumes
4. M. Taylor, A. Al-Dargazelli and S. Hilton in Virtual, augmented, and mixed reality in Healthcare 4.0, Elsevier, 2024.
3. Z. Muwaffak, B.J. Bowles and S. Hilton in 3D Printing in Medicine, D. M. Kalaskar Ed.; Elsevier, 2022.
2. S. Hilton and B. Sil, in Progress in Heterocyclic Chemistry, J. Joule and G. Gribble Eds.; Elsevier, 2020.
1. S. Hilton, S. Rossiter in Three Heterocyclic Rings Fused (5-6-5). In Comprehensive Heterocyclic Chemistry III, A.R. Katritzky, C.A. Ramsden, E.F. V. Scriven and R.J.K. Taylor, Eds.; Elsevier: Oxford, 2008; Vol. 12, pp 711 – 772.
