STEPHEN HILTON

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                                                                    2020                                                               

• M. R. Penny and S.T. Hilton*, Design and Development of 3D Printed Catalytically Active Stirrers for Chemical Synthesis, Reaction Chemistry and Engineering, 2020, 5, 853-858.

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• B. C. Sil, R. B. Belgrave, M. P. Alvaraez, L. Luo, M. Cristofoli, M. R. Penny, D. J. Moore, J. Hardgraft, S. T. Hilton, M. E. Lane, 3D-Printed Franz Cells – An update on Manufacture and Evaluation, International Journal of Cosmetic Science, 2020, DOI - 10.1111/ics.12618.

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                                                            2019                                                        

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• C.R.M. Asquith, B.C. Sil, T. Laitinen, G.J. Tizzard, S.J. Coles, A. Posso, R. Hofmann-Lehmann, S.T. Hilton*, Novel Epidithioketopiperazines as anti-viral zinc ejectors of the Feline Immunodeficiency Virus (FIV) nucleocapsid protein as a model for HIV Infection, Bioorganic and Medicinal Chemistry, 2019, 27, 4174-4184.

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•  C.G. van Melis, M. R. Penny, A. D. Garcia, A. Petti, A.P. Dobbs, S.T. Hilton*, K. Lam*, Supporting‐Electrolyte‐Free Electrochemical Methoxymethylation of Alcohols Using a 3D‐Printed Electrosynthesis Continuous Flow Cell System ChemElectroChem, 2019, 6, 4144-4148.

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•  M.R. Penny, Z.X.Rao, B.F. Peniche, S.T. Hilton*, Modular 3D Printed Compressed Air Driven Continuous-Flow Systems for Chemical Synthesis, European Journal of Organic Chemistry, 2019, 23, 3783-3787.

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•  B. C. Sil, A. Patel, J.M. Crowther, D.J. Moore, J. Hardgraft, S.T. Hilton*, M.E. Lane*, A Preliminary Investigation of Additive manufacture to Fabricate Human Nail Plate Surrogates for Pharmaceutical Testing, Pharmaceutics, 2019, 11, 250.

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• C. R. M. Asquith, T. Laitinen, L. S. Konstantinova, G. Tizzard, A. Poso, O. A. Rakitin, R. Hofmann-Lehmann, S. T. Hilton*, Investigation of the Pentathiepin Functionality as an Inhibitor of Feline Immundeficiency Virus (FIV) via a Potential Zinc Ejection Mechanism, as a Model for HIV Infection, ChemMedChem, 2019, 14, 454-461.

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• S. K. Talapatra, M. R. Penny, S. T. Hilton, F. Kozielski*, Design, 3D-printing and validation of high capacity sitting drop bridges for increased protein crystallisation, Journal of Applied Crystallography, 2019, 52, 171-174.

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                                                                     2018                                                              

• C. R. M. Asquith, L. S. Konstantinova, T. Laitinen, S. J. Coles, O. A. Rakitin, S. T. Hilton*, Exploration and development of a C-H activated route to access the [1,2]dithiolo[4,3-b]indole-3(4H)-thione core and related derivatives, Synlett, 2018, 30, 156-160.

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• B. C. Sil, M. P. Alvarez, Y. Zhang, C.-P Kung, M Hossain, F Iliopoulos, L Luo, J M. Crowther, D J. Moore, J. Hadgraft, M. E. Lane and S. T. Hilton*, 3D printed Franz type diffusion cells, International Journal of Cosmetic Science, 2018, 40(6), 604-609.

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• J. Li, Y. Zhang, B. Sil dos Santos, F. Wang, Y. Ma, C. Perez, Y. Yang, J. Pneg, S. M. Cohen, T-F. Chou, S. T. Hilton*, R. J. Deshaies*, Epidithiodiketopiperazines inhibit protein degradation by targeting proteasome deubiquitinase Rpn11, Cell Chemical Biology, 2018, 25, 1-9.

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• B. R. Szulc, S. T. Hilton, A. Ruiz *, Physiological signature of a novel potentiator of AMPA receptor signalling, Molecular and Cellular Neuroscience, 2018, 92, 82-92.

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• L.V. Kerai, J. Bardes, S. Hilton, S. Murdan*, Two strategies to enhance ungual drug permeation from UV-cured films: Incomplete polymerisation to increase drug release and incorporation of chemical enhancers, European Journal of Pharmaceutical Sciences 2018,123, 217-227.

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• Rao, Z. X., Patel, B., Monaco, A., Cao, Z. J., Barniol-Xicota, M., Pichon, E., Ladlow, M. and Hilton, S. T. (2017) ‘3D-Printed Polypropylene Continuous-Flow Column Reactors: Exploration of Reactor Utility in S N Ar Reactions and the Synthesis of Bicyclic and Tetracyclic Heterocycles’, European Journal of Organic Chemistry. doi: 10.1002/ejoc.201701111.

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• Penny, M. R., Cao, Z. J., Patel, B., Sil dos Santos, B., Asquith, C. R. M., Szulc, B. R., Rao, Z. X., Muwaffak, Z., Malkinson, J. P. and Hilton, S. T. (2017) ‘Three-Dimensional Printing of a Scalable Molecular Model and Orbital Kit for Organic Chemistry Teaching and Learning’, Journal of Chemical Education. American Chemical Society and Division of Chemical Education, Inc., 94(9), pp. 1265–1271. doi: 10.1021/acs.jchemed.6b00953.

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• Muwaffak, Z., Goyanes, A., Clark, V., Basit, A. W., Hilton, S. T. and Gaisford, S. (2017) ‘Patient-specific 3D scanned and 3D printed antimicrobial polycaprolactone wound dressings’, International Journal of Pharmaceutics, 527(1–2), pp. 161–170. doi: 10.1016/j.ijpharm.2017.04.077.

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• Mohmmed, S. A., Vianna, M. E., Penny, M. R., Hilton, S. T. and Knowles, J. C. (2017) ‘The effect of sodium hypochlorite concentration and irrigation needle extension on biofilm removal from a simulated root canal model’, Australian Endodontic Journal. doi: 10.1111/aej.12203.

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• Monaco, A., Szulc, B. R., Rao, Z. X., Barniol-Xicota, M., Sehailia, M., Borges, B. M. A. and Hilton, S. T. (2017) ‘Short Total Synthesis of (±)-γ-Lycorane by a Sequential Intramolecular Acylal Cyclisation (IAC) and Intramolecular Heck Addition Reaction’, Chemistry - A European Journal, 23(20), pp. 4750–4755. doi: 10.1002/chem.201700143.

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• Mohmmed, S. A., Vianna, M. E., Penny, M. R., Hilton, S. T., Mordan, N. and Knowles, J. C. (2017) ‘Confocal laser scanning, scanning electron, and transmission electron microscopy investigation of Enterococcus faecalis biofilm degradation using passive and active sodium hypochlorite irrigation within a simulated root canal model’, MicrobiologyOpen, 6(4), p. e00455. doi: 10.1002/mbo3.455.

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• Mohmmed, S. A., Vianna, M. E., Hilton, S. T., Boniface, D. R., Ng, Y.-L. and Knowles, J. C. (2017) ‘Investigation to test potential stereolithography materials for development of an in vitro root canal model’, Microscopy Research and Technique, 80(2), pp. 202–210. doi: 10.1002/jemt.22788.

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                                                                                2016                                                                                

• Kerai, L., Hilton, S., Maugueret, M., Kazi, B., Faull, J., Bhakta, S. and Murdan, S. (2016) ‘UV-curable gels as topical nail medicines:In vivo residence, anti-fungal efficacy and influence of gel components on their properties’, International Journal of Pharmaceutics, 514(1), pp. 244–254. doi: 10.1016/j.ijpharm.2016.08.025.

• Alband, M., Lee, R., Penny, M., Brocchini, S. and Hilton, S. (2016) ‘Assessment of Adhesion Response To 3D Printed Materials For Ophthalmic Device Development’, Value in Health. Elsevier, 19(7), p. A564. doi: 10.1016/j.jval.2016.09.1257.

• Alarab Mohmmed, S., Vianna, M. E., Penny, M. R., Hilton, S. T., Mordan, N. and Knowles, J. C. (2016) ‘A novel experimental approach to investigate the effect of different agitation methods using sodium hypochlorite as an irrigant on the rate of bacterial biofilm removal from the wall of a simulated root canal model’, Dental Materials, 32(10), pp. 1289–1300. doi: 10.1016/j.dental.2016.07.013.

• Asquith, C. R. M., Konstantinova, L. S., Laitinen, T., Meli, M. L., Poso, A., Rakitin, O. A., Hofmann-Lehmann, R. and Hilton, S. T. (2016) ‘Evaluation of Substituted 1,2,3-Dithiazoles as Inhibitors of the Feline Immunodeficiency Virus (FIV) Nucleocapsid Protein via a Proposed Zinc Ejection Mechanism’, ChemMedChem, 11(19), pp. 2119–2126. doi: 10.1002/cmdc.201600260.

• Asquith, C. (2016) ‘The viral Achilles heel: The Nucleocapsid protein of FIV/HIV and related lentiviruses as a therapeutic target’, Doctoral thesis, UCL (University College London).

• Lee, R. M., Alband, M., Penny, M., Hilton, S. T., Brocchini, S., Khaw, P. T. and Uusitalo, H. M. (2016) ‘Cell adhesion and protein adsorption studies of 3D printed photopolymers Conjunctival tissue proteome demonstrates abnormal expression of wound response proteins in glaucoma patients’, ARVO 2016: Association for Research in Vision and Ophthalmology, 57(12), p. 2923.

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                                                                                  2015                                                                              

• Szulc, B. R., Sil, B. C., Ruiz, A. and Hilton, S. T. (2015) ‘A Common Precursor Approach to Structurally Diverse Natural Products: The Synthesis of the Core Structure of (±)-Clausenamide and the Total Synthesis of (±)-Hyalodendrin’, European Journal of Organic Chemistry. WILEY‐VCH Verlag, 2015(34), pp. 7438–7442. doi: 10.1002/ejoc.201501256.

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• Buanz, A., Gaisford, S. and Hilton, S. (2015) ‘Foreword: SI printing pharmaceuticals’, International Journal of Pharmaceutics, 494(2), p. 553. doi: 10.1016/j.ijpharm.2015.05.044.

• Tyson, A. L., Hilton, S. T. and Andreae, L. C. (2015) ‘Rapid, simple and inexpensive production of custom 3D printed equipment for large-volume fluorescence microscopy’, International Journal of Pharmaceutics, 494(2), pp. 651–656. doi: 10.1016/j.ijpharm.2015.03.042.

• Monaco, A., Aliev, A. E. and Hilton, S. T. (2015) ‘Intramolecular Acylal Cyclisation (IAC) as an Efficient Synthetic Strategy towards the Total Synthesis of Erythrina Alkaloid Derivatives’, Chemistry - A European Journal. WILEY‐VCH Verlag, 21(40), pp. 13909–13912. doi: 10.1002/chem.201502436.

• Kerai, L. V., Hilton, S. and Murdan, S. (2015) ‘UV-curable gel formulations: Potential drug carriers for the topical treatment of nail diseases’, International Journal of Pharmaceutics, 492 (1-2), pp. 177–190. doi: 10.1016/j.ijpharm.2015.07.020.

• Asquith, C. R. M., Meli, M. L., Konstantinova, L. S., Laitinen, T., Poso, A., Rakitin, O. A., Hofmann-Lehmann, R., Allenspach, K. and Hilton, S. T. (2015) ‘Novel fused tetrathiocines as antivirals that target the nucleocapsid zinc finger containing protein of the feline immunodeficiency virus (FIV) as a model of HIV infection’, Bioorganic & Medicinal Chemistry Letters, 25(6), pp. 1352–1355. doi: 10.1016/j.bmcl.2014.12.047.

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                                                                                2014                                                                                

• Patel, B. and Hilton, S. (2014) ‘A Radical-Mediated Approach to the Total Synthesis of Fluorinated Marinoquinoline A and Related Tricyclic and Tetracyclic Congeners’, Synlett, 26(1), pp. 79–83. doi: 10.1055/s-0034-1378614.

• Asquith, C. R. M., Meli, M. L., Konstantinova, L. S., Laitinen, T., Peräkylä, M., Poso, A., Rakitin, O. A., Allenspach, K., Hofmann-Lehmann, R. and Hilton, S. T. (2014) ‘Evaluation of the antiviral efficacy of bis[1,2]dithiolo[1,4]thiazines and bis[1,2]dithiolopyrrole derivatives against the nucelocapsid protein of the Feline Immunodeficiency Virus (FIV) as a model for HIV infection’, Bioorganic & Medicinal Chemistry Letters, 24(12), pp. 2640–2644. doi: 10.1016/j.bmcl.2014.04.073.

• Patel, B., Saviolaki, G., Ayats, C., Garcia, M. A. E., Kapadia, T. and Hilton, S. T. (2014) ‘Tuneable radical cyclisations: a tin-free approach towards tricyclic and spirocyclic heterocycles via a common precursor’, RSC Adv. Royal Society of Chemistry, 4(36), pp. 18930–18932. doi: 10.1039/C4RA02420F.

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2013

• Sil, B. and Hilton, S. (2013) ‘A Mild and Convenient Base-Catalysed Approach to Disubstituted Epidithiodiketopiperazines’, Synlett, 24(19), pp. 2563–2566. doi: 10.1055/s-0033-1340161.

• Mpima, S., Ohnmacht, S. A., Barletta, M., Husby, J., Pett, L. C., Gunaratnam, M., Hilton, S. T. and Neidle, S. (2013) ‘The influence of positional isomerism on G-quadruplex binding and anti-proliferative activity of tetra-substituted naphthalene diimide compounds’, Bioorganic & Medicinal Chemistry, 21(20), pp. 6162–6170. doi: 10.1016/j.bmc.2013.05.027.

• Patel, A. R., Schatteman, D., Vos, W. H. De and Dewettinck, K. (2013) ‘Shellac as a natural material to structure a liquid oil-based thermo reversible soft matter system’, RSC Advances. The Royal Society of Chemistry, 3(16), p. 5324. doi: 10.1039/c3ra40934a.

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2010

• Mirizzi, D., Hilton, S. T. and Jones, K. (2010) ‘Heteroaryl Radicals Review’, Advances in Heterocyclic Chemistry, 100, pp. 101–143. doi: 10.1016/S0065-2725(10)10004-X.

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2009

• Hilton, S., Naud, S., Caldwell, J. J., Boxall, K., Burns, S., Anderson, V. E., Antoni, L., Allen, C. E., Pearl, L. H., Oliver, A. W., Aherne, G. W., Garrett, M. D. and Collins, I. (2009) ‘Identification and characterisation of 2-aminopyridine inhibitors of checkpoint kinase 2’, Bioorganic & Medicinal Chemistry, 18(2), pp. 707–718. doi: 10.1016/j.bmc.2009.11.058.

• Cook, K. M., Hilton, S. T., Mecinovic, J., Motherwell, W. B., Figg, W. D. and Schofield, C. J. (2009) ‘Epidithiodiketopiperazines block the interaction between hypoxia-inducible factor-1alpha (HIF-1alpha) and p300 by a zinc ejection mechanism’, The Journal of biological chemistry. American Society for Biochemistry and Molecular Biology, 284(39), pp. 26831–8. doi: 10.1074/jbc.M109.009498.

• Hilton, S. (2009) ‘The hypoxia inducible factor-1α and p300 interaction as a therapeutic target of the epidithiodiketopiperazine class of natural products’, Journal of Pharmacy and Pharmacology, 61, pp. A152–A153. 

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2008

• Cook, K., Hilton, S.T., Schofield, C and Figg, W. (2008) ‘A promising cancer target: lead compounds blocking the HIF-1α/p300 interaction’. American Association for Cancer Research, 68, pp. 4149-4149. 

• Hilton, S. T. and Rossiter, S. (2008) ‘Three Heterocyclic Rings Fused (5-6-5)’, in Comprehensive Heterocyclic Chemistry III: A Review of the Literature 1995-2007. Oxford: Elsevier Science, pp. 711–772. ISBN: 0080449913. 

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2007

• Brown, R., Plumb, J., Ahearne, G., McDonald, E., Jones, K. and Hilton, S. (2007) ‘Preparation of 2-[3H]-thiazol-2-ylidine-methylpyridine and related compounds and their use as antitumor agents’. Patent.

• Brown, R., Plumb, J., Ahearne, G., McDonald, E., Jones, K. and Hilton, S. (2007) ‘2-[3h-thiazol-2-ylidinemethyl]pyridines and related compounds and their use’. Patent.

• Hilton, S. T. and Jones, K. (2006) ‘The tandem radical route to indole alkaloids: an unusual rearrangement reaction’, Arkivoc. Michigan Publishing, University of Michigan Library, 2007(11), p. 120. doi: 10.3998/ark.5550190.0008.b11.

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2006

• Aliev, A. E., Hilton, S. T., Motherwell, W. B. and Selwood, D. L. (2006) ‘A concise approach to the epidithiodiketopiperazine (ETP) core’, Tetrahedron Letters, 47(14). doi: 10.1016/j.tetlet.2006.01.156.

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2005

• Hilton, S. T., Motherwell, W. B., Potier, P., Pradet, C. and Selwood, D. L. (2005) ‘Observations on the reactivity of thiyl radicals derived from 3,6-epidithiodiketopiperazine-2,5-diones and related congeners’, Bioorganic & Medicinal Chemistry Letters, 15(9). doi: 10.1016/j.bmcl.2005.03.022.

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2004

• Denison, S. and Hilton, S. (2004) ‘A Convenient Synthesis of 2-Cyano-3-Substituted Indoles’, Synlett, 2004(15), pp. 2806–2808. doi: 10.1055/s-2004-835627.

• Hilton, S., Motherwell, W. and Selwood, D. (2004) ‘An Expedient Entry into the α-Mercaptodiketopiperazine Nucleus’, Synlett, 2004(14), pp. 2609–2611. doi: 10.1055/s-2004-834823.

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2003

• Hilton, S. (2002) ‘Towards the synthesis of indole alkaloids’. Kingston University. Thesis. 

• Hilton, S. T., Jones, K., Ho, T. C. T., Pljevaljcic, G. and Schulte, M. (2001) ‘A tandem radical approach to the ABCE-rings of the Aspidosperma and Strychnos alkaloids’, Chemical Communications. The Royal Society of Chemistry, 0(2), pp. 209–210. doi: 10.1039/b008465o.

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2000

• Stephen T. Hilton, Tim C. T. Ho, Goran Pljevaljcic, and and Jones*, K. (2000) ‘A New Route to Spirooxindoles’. American Chemical Society . doi: 10.1021/OL0061642.

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